Methods and compositions for inhibition of STAT3
AssigneeOhio State Innovation Foundation
InventorsYuhong Yang, Chenglong Li, Michael Racke
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Abstract
In one aspect, the disclosure relates to prodrug compositions of a STAT inhibitor compound. In some aspects, the STAT is STAT3. Disclosed are pharmaceutical compositions comprising the prodrug inhibitors of STAT. In various aspects, the prodrug inhibitors of STAT can be used in methods of treating an inflammatory disorder, including multiple sclerosis, or a disorder of uncontrolled cellular proliferation, such as a cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
Claims19
A method for ameliorating or alleviating cancer in a mammal comprising the step of administering to the mammal a therapeutically effective amount of at least one compound having a structure represented by a formula,
- wherein each of R1 and R2 is independently selected from hydrogen and C1-C6 alkyl;
- wherein each of R3, R4, R5, R7, R8, and R9 is independently selected from hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, —NO2, —NH2, and —OH;
- and
- wherein R20 is selected from —C(O)—O—(C1-C6 alkylene), —C(O)—(C1-C6 alkylene), —C(O)—(C1-C6 alkylene)-C(O)OH, —C(O)—NR21R22, and —(C1-C6 alkylene)-PO3H2;
- wherein each of R21 and R22 is independently selected from hydrogen and C1-C6 alkyl;
- or a pharmaceutically acceptable salt thereof.
A method for ameliorating or alleviating cancer in a mammal comprising the step of administering to the mammal a therapeutically effective amount of at least one compound having a structure represented by a formula:
- wherein each of R3, R4, R5, R7, R8, and R9 is independently selected from hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, —NO2, —NH2, and —OH;
- and
- wherein R20 is selected from —C(O)—O—(C1-C6 alkylene), —C(O)—(C1-C6 alkylene), —C(O)—(C1-C6 alkylene)-C(O)OH, —C(O)—NR21R22, and —(C1-C6 alkylene)-PO3H2;
- wherein each of R21 and R22 is independently selected from hydrogen and C1-C6 alkyl;
- or a pharmaceutically acceptable salt thereof.
A method for inhibiting STAT3 in a mammal comprising the step of administering to the mammal a therapeutically effective amount of at least one compound having a structure represented by a formula,
- wherein each of R1 and R2 is independently selected from hydrogen and C1-C6 alkyl;
- wherein each of R3, R4, R5, R7, R8, and R9 is independently selected from hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, —NO2, —NH2, and —OH;
- and
- wherein R20 is selected from —C(O)—O—(C1-C6 alkylene), —C(O)—(C1-C6 alkylene), —C(O)—(C1-C6 alkylene)-C(O)OH, —C(O)—NR21R22, and —(C1-C6 alkylene)-PO3H2;
- wherein each of R21 and R22 is independently selected from hydrogen and C1-C6 alkyl;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.