Inhibitors of MHC-I Nef downmodulation for treating HIV
AssigneeThe Regents of the University of Michigan
InventorsDavid H. Sherman, Kathleen L. Collins, Andrew W. Robertson, Mark M. Painter
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Abstract
Provided herein are compounds that can inhibit MHC-I downmodulation, and treat HIV infection in a patient in need of treatment thereof.
Claims18
A method of treating human immunodeficiency virus (HIV) infection in a patient in need thereof comprising administering to the patient a pharmaceutically-effective amount of a compound having a structure of Formula (I), or a pharmaceutically acceptable salt thereof:
- wherein
- or represents a direct bond;
- R1 is H, C(O)R6, or a sugar moiety;
- R2 is H or OH;
- R3 is H, C(O)R7 or a sugar moiety;
- each R4 is independently H or C1-6alkyl;
- R5 is C1-6alkyl or C2-6alkenyl;
- and
- R6 and R7 are each independently C1-6 alkyl.
A method of treating human immunodeficiency virus (HIV) infection comprising administering to a patient in need thereof a pharmaceutically-effective amount of a compound, or pharmaceutically acceptable salt thereof, having a structure as shown in Table A:
- TABLE A
- Compound
- No.
- Structure
- A1
- A2
Dependencies are inferred from the claim text.