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US 12,594,254 B2Granted
Intranasal administration of n-acetylcysteine and uses thereof
AssigneeNeuronasal, Inc.
InventorsDouglas A. Greene, Thomas I. Bradshaw
Life of this patent
Estimating the term…
Abstract
The present disclosure describes methods comprising administering N-acetylcysteine (NAC) or a pharmaceutically-acceptable salt or congener thereof. The disclosed methods can be used to treat a brain disorder.
Claims43
A method comprising administering to a subject in need thereof:
- a) a dose of a compound, wherein the compound is N-acetylcysteine (NAC) or a pharmaceutically-acceptable salt thereof or glutathione (GSH);
- and
- b) a therapeutically-effective amount of a therapeutic agent,
- wherein the administering delivers the therapeutic agent to a brain tissue of the subject in an amount that is at least about 20% greater than an amount of the therapeutic agent delivered to the brain tissue of the subject when administered without the dose of the compound.
1 more element
A method of treating a brain disorder in a subject in need thereof, the method comprising intranasally administering to a nose of the subject:
- a) a dose of a compound, wherein the compound is N-acetylcysteine (NAC) or a pharmaceutically-acceptable salt thereof or glutathione (GSH);
- and
- b) a therapeutically-effective amount of a therapeutic agent, wherein the brain disorder is any of a traumatic brain injury, a mild traumatic brain injury, a concussion, post-concussion syndrome, a stroke, a neurodegenerative disease, dementia, Parkinson's disease, or an age-related disorder.
Dependencies are inferred from the claim text.