Protection of biological species from degradation
AssigneeSisaf Limited
InventorsRoghieh Suzanne Saffie-Siebert, Flavia Sutera
Life of this patent
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Abstract
A method of preparing an injectable or oral storage stable formulation, comprising: contacting a biological species with a delivery system comprising biocompatible solid particles to form a complex; then optionally, lyophilising the complex to form a powder, and then dispersing the complex in a biodegradable gel material to form the formulation, comprising the complex embedded in the biodegradable gel material. Also related products, methods, and medical uses.
Claims23
A method of preparing an injectable or oral storage stable formulation, comprising:
- (i) contacting a biological species with a delivery system comprising (a) biocompatible solid particles that comprise hydrolysable silicon and (b) a lipid component comprising a cationic lipid and/or an ionisable lipid, to form a complex;
- then
- (ii) optionally, lyophilising the complex to form a powder;
- and then
- (iii) dispersing the complex in a biodegradable gel material to form the formulation, comprising the complex embedded in the biodegradable gel material.
An injectable or oral storage stable formulation, comprising a biodegradable gel material in which is embedded a biological species complexed to a delivery system comprising biocompatible solid particles that comprise hydrolysable silicon, a lipid component comprising a cationic lipid and/or an ionisable lipid, and, optionally, a non-reducing disaccharide.
A method of protecting a biological species from degradation, comprising:
- (i) contacting the biological species with a delivery system comprising (a) biocompatible solid particles that comprise hydrolysable silicon and (b) a lipid component comprising a cationic lipid and/or an ionisable lipid, to form a complex;
- then
- (ii) optionally, lyophilising the complex to form a powder;
- and then
- (iii) dispersing the complex in a biodegradable gel material to form an oral or injectable formulation comprising the complex embedded in the biodegradable gel material.
Dependencies are inferred from the claim text.