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US 12,594,237 B2Granted
Mucoadhesive gel composition
AssigneeViramal Limited
InventorsWilliam Bologna, Francois Boutignon, Lea Louvel, Finn Larsen, Simona Fiore, Oliver Bates
Life of this patent
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Abstract
A pharmaceutical mucoadhesive gel composition for delivering therapeutic agents (such as progesterone) by buccal, nasal, vaginal and rectal administration, thereby avoiding the hepatic first-pass metabolism. The gel composition comprises a vehicle with a gel-forming agent and a bioadhesive agent; and a therapeutic agent dispersed or suspended in the vehicle.
Claims15
A pharmaceutical mucoadhesive gel composition, comprising:
- (a) a vehicle comprising:
- (i) a gel-forming agent, wherein the gel-forming agent is selected from the group consisting of:
- ethyl cellulose, methyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose, and salts thereof;
- (ii) a bioadhesive agent, wherein the bioadhesive agent is a mixed sodium and calcium salt of a poly(methyl vinyl ether-co-maleic anhydride) copolymer, or a poly(acrylic acid)-containing polymer;
- and
- (iii) an oil composition, wherein the oil composition comprises a mixture of liquid paraffin and petrolatum;
- and
- (b) at least one micronized therapeutic agent, wherein the at least one micronized therapeutic agent comprises a cannabinoid;
- and
- wherein the pharmaceutical mucoadhesive gel composition has a viscosity in the range of about 139.5 Pascal seconds (Pa·s) up to about 418.5 Pa·s at about 21 degrees Celsius.
7 more elements
A pharmaceutical mucoadhesive gel composition, comprising:
- (a) a vehicle comprising:
- (i) a gel-forming agent, wherein the gel-forming agent is selected from the group consisting of:
- ethyl cellulose, methyl cellulose, carboxymethyl cellulose, hydroxypropyl cellulose, and salts thereof;
- (ii) a bioadhesive agent, wherein the bioadhesive agent is a mixed sodium and calcium salt of a poly(methyl vinyl ether-co-maleic anhydride) copolymer, or a poly(acrylic acid)-containing polymer;
- and
- (iii) an oil composition, wherein the oil composition comprises a mixture of liquid paraffin and petrolatum;
- and
- (b) a micronized therapeutic agent, wherein the micronized therapeutic agent comprises a steroid hormone, a prostaglandin, or a cannabinoid;
- and
- (c) a vitamin, a mineral, or iron,
- wherein the pharmaceutical mucoadhesive gel composition has a viscosity in the range of about 139.5 Pascal seconds (Pa·s) up to about 418.5 Pa·s at about 21 degrees Celsius.
8 more elements
Dependencies are inferred from the claim text.