Systems, methods, and media for presenting biophysical simulations in an interactive mixed reality environment

A method for presenting biophysical simulations in an interactive mixed reality environment, comprising:

• receiving medical imaging data associated with a subject, the medical imaging data comprising T1-weighted magnetic resonance imaging (MRI) data, T2-weighted MRI data, or computed tomography (CT) data corresponding to the subject's brain tissue;
• receiving, from a server, information useable to visualize a simulation of one or more biophysical processes associated with the subject in connection with a subject-specific anatomical model associated with the subject based on the medical imaging data with an instrument in a first position, wherein the server generates the subject-specific anatomical model based on the medical imaging data by using a nonlinear transformation matrix and a warp field with an anatomical atlas;
• causing a visualization of the simulation to be presented, via a transparent display of a head mounted display device, in connection with the medical imaging data with the instrument presented in the first position;
• receiving, from the server, updated information useable to visualize an updated simulation of the one or more biophysical processes in connection with the subject-specific anatomical model based on the medical imaging data with the instrument in a second position;
• and
• causing a visualization of the updated simulation to be presented, via the transparent display, in connection with the medical imaging data with the instrument presented in the second position.

A non-transitory computer readable medium containing computer executable instructions that, when executed by processing circuitry, cause the processing circuitry to:

• receive medical imaging data associated with a subject, the medical imaging data comprising computed tomography (CT) data corresponding to the subject's brain tissue;
• receive, from a server, information useable to visualize a simulation of one or more biophysical processes associated with the subject in connection with a subject-specific anatomical model associated with the subject based on the medical imaging data with an instrument in a first position, wherein the server generates the subject-specific anatomical model based on the medical imaging data by using a nonlinear transformation matrix and a warp field with an anatomical atlas;
• cause a visualization of the simulation to be presented, via a transparent display of a head mounted display device, in connection with the medical imaging data with the instrument presented in the first position;
• receive, from the server, updated information useable to visualize an updated simulation of the one or more biophysical processes in connection with the subject-specific anatomical model based on the medical imaging data with the instrument in a second position;
• and
• cause a visualization of the updated simulation to be presented, via the transparent display, in connection with the medical imaging data with the instrument presented in the second position.