Patient-specific neuromodulation alignment structures

A method of configuring a wearable device, comprising:

• applying the wearable device to a subject, wherein the wearable device comprises a belt or a vest, wherein an ultrasound probe is coupled to a positioning structure of the wearable device via a probe holder, and wherein the ultrasound probe comprises one or more ultrasound transducers, wherein the one or more ultrasound transducers are configured to emit a therapy beam and the one or more ultrasound transducers are configured to emit an imaging beam;
• adjusting the probe holder relative to the subject to change a rock, a tilt, or a spin angular orientation of the ultrasound probe, wherein the probe holder comprises a probe carriage frame, wherein the probe carriage frame comprises a passage that receives the ultrasound probe, and wherein the probe carriage frame is configured to move in a z-dimension, wherein the z-dimension comprises a linear axial dimension toward or away from the subject;
• determining one or more fitting parameters of the wearable device, the positioning structure, or the ultrasound probe when aligned to an anatomic target region of the subject, wherein the wearable device comprises one or more adjustable fitting features, wherein the one or more adjustable fitting features comprise tensioning features configured to hold the ultrasound probe against the subject with applied pressure;
• and
• saving the one or more fitting parameters for use when the wearable device is subsequently applied to the subject for a therapy session.