Minimally invasive skin patch, method of manufacturing same, and blood glucose measuring apparatus using same

A blood glucose measuring apparatus comprising:

• a patch comprising a skin attachment surface, a reaction layer which reacts with glycation products of skin, and a plurality of microneedles disposed on the skin attachment surface to guide the glycation products of the skin to the reaction layer;
• a reaction detector which emits light to the reaction layer and receives light reflected by the reaction layer to detect reactivity of the glycation products;
• and
• an optical trap disposed on the reaction layer, the optical trap allowing only one ray of light to pass therethrough and arrive on the reaction detector, wherein the only one ray of light is reflected by the reaction layer of the patch and is one of light reflected by a portion in which a microneedle of the plurality of microneedles is disposed and light reflected by a portion in which the microneedle is not disposed, wherein the optical trap is on an upper surface of the patch opposite the skin attachment surface, and separated from the plurality of microneedles by a body of the patch between the upper surface and the skin attachment surface;
• wherein the optical trap and the reaction layer extend across the plurality of microneedles in a direction orthogonal to a projection direction of the plurality of microneedles;
• and
• wherein the optical trap comprises
• light passing parts which allow light to pass therethrough, and
• light blocking parts which block light, and
• the light passing parts and the light blocking parts alternate in a planar pattern,
• wherein the light passing parts and the light blocking parts are in contact with the upper surface of the reaction layer, and
• wherein
• each of the light passing parts aligns in the direction orthogonal to the projection direction of the plurality of microneedles with a corresponding microneedle of the plurality of microneedles and with one of first portions of the reaction layer having a concentration of the reactant expressed to be darker than a concentration of the reactant in second portions of the reaction layer, and
• each of the light blocking parts aligns in the direction orthogonal to the projection direction of the plurality of microneedles with one of the second portions of the reaction layer and with a portion of the skin attachment surface that extends across a space between a pair of adjacent microneedles, and
• wherein
• the reaction layer is at least partly within the body of the patch, and
• the optical trap is outside the body of the patch and in direct contact with an upper surface of the reaction layer.