Method and device for determining a coronary microvascular resistance score

A data processing device comprising:

• an input configured to:
• obtain acquired blood pressure data of a cardiac vessel supplying blood to myocardial tissue of a mammal, said acquired blood pressure data being acquired while the mammal is in a first physiological state;
• obtain acquired flow data of the blood in the cardiac vessel, said acquired flow data being acquired while the mammal is in the first physiological state;
• obtain throughflow data indicative of a geometry of the cardiac vessel, said flowthrough data being acquired by:
• measuring a length of the cardiac vessel from a proximal point to a distal point,
• measuring a transit time of the blood from the proximal point to the distal point, and
• dividing the length by the transit time to calculate the throughflow data;
• a processor configured to:
• generate adjusted blood pressure data corresponding to a second physiological state, based on the acquired blood pressure data and the first physiological state;
• generate adjusted flow data corresponding to the second physiological state, based on the acquired flow data and the first physiological state;
• generate a microvascular resistance score, based on the adjusted blood pressure data, the adjusted flow data and the throughflow data;
• and
• an output configured to:
• provide, through an electronic output signal, the microvascular resistance score for display on a display module of an electronic computing device comprising the data processing device, for a user of the electronic computing device to evaluate perfusion of the myocardial tissue.

A computer program product comprising instructions which, when the program is executed by a computer, cause the computer to carry out a method of determining a microvascular resistance score, the method comprising:

• obtaining acquired blood pressure data of a cardiac vessel supplying blood to myocardial tissue of a mammal, said acquired blood pressure data being acquired while the mammal is in a first physiological state;
• obtaining acquired flow data of the blood in the cardiac vessel, said acquired flow data being acquired while the mammal is in the first physiological state;
• obtaining throughflow data indicative of a geometry of the cardiac vessel, said throughflow data being acquired by:
• measuring a length of the cardiac vessel from a proximal point to a distal point,
• measuring a transit time of the blood from the proximal point to the distal point, and
• dividing the length by the transit time to calculate the throughflow data;
• generating adjusted blood pressure data corresponding to a second physiological state, based on the acquired blood pressure data and the first physiological state;
• generating adjusted flow data corresponding to the second physiological state, based on the acquired flow data and the first physiological state;
• generating the microvascular resistance score, based on the adjusted blood pressure data, the adjusted flow data and the throughflow data;
• and
• providing, through an electronic output signal, the microvascular resistance score for display on a display module of an electronic computing device, for a user of the electronic computing device to evaluate perfusion of the myocardial tissue.

A non-transitory computer readable medium comprising instructions which, when executed by a computer, cause the computer to carry out a method of determining a microvascular resistance score, the method comprising:

• obtaining acquired blood pressure data of a cardiac vessel supplying blood to myocardial tissue of a mammal, said blood pressure data being acquired while the mammal is in a first physiological state;
• obtaining acquired flow data of the blood in the cardiac vessel, said acquired flow data being acquired while the mammal is in the first physiological state;
• obtaining throughflow data indicative of a geometry of the cardiac vessel, said throughflow data being acquired by:
• measuring a length of the cardiac vessel from a proximal point to a distal point,
• measuring a transit time of the blood from the proximal point to the distal point, and
• dividing the length by the transit time to calculate the throughflow data;
• generating adjusted blood pressure data corresponding to a second physiological state, based on the acquired blood pressure data and the first physiological state;
• generating adjusted flow data corresponding to the second physiological state, based on the acquired flow data and the first physiological state;
• generating the microvascular resistance score, based on the adjusted blood pressure data, the adjusted flow data and the throughflow data;
• and
• providing, through an electronic output signal, the microvascular resistance score for display on a display module of an electronic computing device, for a user of the electronic computing device to evaluate perfusion of the myocardial tissue.