Variable-size hydrophobically-modified polymers
AssigneeMedcura, Inc.
InventorMatthew Dowling
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Abstract
In various aspects, the invention provides compositions of variable-length hydrophobically-modified polymers. These variable-length hydrophobes decorated along the hydrophilic polymer backbone provide advanced properties and allow for precise control over the behavior of the resulting amphiphilic polymer, including in aqueous solution. Such control allows for enhanced functionality of the amphiphilic polymer relative to standard single-length hydrophobe grafting designs, including for hemostasis.
Claims7
A film composition comprising a hydrophobically-modified chitosan having hydrophobic groups comprising a C1 to C4 hydrocarbon and a C6 to C12 hydrocarbon, wherein the hydrophobic groups are conjugated to the chitosan backbone by fatty acid anhydride chemistry, wherein the hydrophobically-modified chitosan has from about 10% to about 50% of functional groups occupied by a hydrophobic group, wherein the C1 to C4 hydrocarbon groups are incorporated at 20 mol % to 40 mol % with respect to chitosan available amines, and
- wherein the film is formed from a dried acid solution of the hydrophobically-modified chitosan and a synthetic polymer consisting of polyvinyl alcohol, and wherein the solution is an aqueous solution;
- wherein the film is not a viscoelastic composition comprising a cross-linker.
Dependencies are inferred from the claim text.