Methods and treatment of trauma

A method for reducing levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in a trauma patient in need thereof comprising administering stored oxygen reduced blood to the trauma patient in need thereof, the stored oxygen reduced blood comprising a blood product having a reduced oxygen saturation level prior to and during storage, wherein the trauma patient in need thereof has liver injury or liver damage, wherein the trauma patient in need thereof has elevated levels of AST and ALT prior to the administering, and wherein the levels of AST and ALT are each reduced independently by at least 5% in the trauma patient in need thereof after the administering as compared to a trauma patient administered non-oxygen reduced blood stored under conventional conditions.