Systems and methods for treating an opioid-induced adverse pharmacodynamic response

A method of treating or preventing an opioid-induced adverse pharmacodynamic response in a patient identified in need thereof, comprising concurrently administering to the patient

• (i) an analgesically effective amount of oxycodone or a pharmaceutically acceptable salt thereof, and
• (ii) an effective amount of buprenorphine or a pharmaceutically acceptable salt thereof to treat or prevent said adverse pharmacodynamic response in the patient,
• Wherein the administration of buprenorphine or pharmaceutically acceptable salt thereof does not attenuate analgesic effects produced by said oxycodone or pharmaceutically acceptable salt thereof;
• wherein the patient is on a chronic opioid therapy or an opioid naïve patient.