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US 12,565,517 B2Granted
Cyclic peptide having CTLA-4 inhibitory activity and use thereof
AssigneeGeneFrontier Corporation
InventorsKanehisa Kojoh, Kumiko Tsuihiji, Shizue Katoh, Mikiko Nakamura
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Abstract
The present invention provides a cyclic peptide which comprises the amino acid sequence represented by formula (I) X1-His-Pro-X4-Leu-X6-X7-X8-Ser-X10-His-Phe (I) in the cycle and has an activity to specifically bind to human CTLA-4, wherein X1, X4, X6, X7, X8 and X10 are each independently any amino acid.
Claims16
A cyclic peptide having a cyclic structure formed by an intrapeptide bond between two amino acids in the peptide, which comprises the amino acid sequence represented by formula (I):
- X1-His-Pro-X4-Leu-X6-X7-X8-Ser-X10-His-Phe (I) (SEQ ID NO:
- 212)
- in the cyclic structure and has an activity to specifically bind to human CTLA-4, wherein X1, X4, X6, X7, X8 and X10 are each independently any amino acid.
Dependencies are inferred from the claim text.