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US 12,551,527 B2Granted
Drug delivery systems for treatment of infections
AssigneeWayne State University
InventorsArun K. Iyer, Samaresh Sau, Michael Rybak, Ketki Bhise, Razie Kebriaei
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Abstract
Lipid-based drug delivery vehicles (including liposomal nanoparticles) are described which include antibiotic(s) for the treatment of infections, such as Methicillin-Resistant Staphylococcus (S.) aureus (MRSA) infections and Methicillin-Susceptible S. aureus (MSSA) infections. These drug delivery vehicles have high drug-loading, do not accumulate in the liver, and can optionally include one or more targeting ligands.
Claims14
A method of treating Staphylococcus (S.) aureus infection in a subject in need thereof, comprising:
- administering a therapeutically effective amount of a drug delivery system comprising vancomycin and cefazolin to the subject wherein the drug delivery system comprises a liposomal nanoparticle comprising:
- a lipid component comprising:
- a 1:0.5:0.07 ratio of hydro soy phosphatidylcholine (HSPC) to cholesterol to methoxyl polyethylene glycol (PEG)-ylated distearoyl-phosphatidyl-ethanolamine (DSPE-mPEG), or
- a 1:0.05:0.007:0.007 ratio of HSPC to cholesterol to DSPE-mPEG to DSPE-PEG-Folate, or
- a 1:0.5:0.07 ratio of N-(1-(2,3-dioleoyloxy) propyl)-N,N,N-trimethylammonium chloride (DOTAP) to cholesterol to DSPE-mPEG;
- and
- wherein the liposomal nanoparticle encapsulates:
- at least 10% vancomycin;
- and
- cefazolin, and
- wherein the nanoparticle comprises a 1:1 drug:lipid ratio,
- thereby treating the S. aureus infection in the subject.
9 more elements
Dependencies are inferred from the claim text.