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US 12,550,924 B2Granted
Compositions derived from gastrointestinal tract mucins
AssigneeGnubiotics Sciences SA
InventorsAdeyemi Adesokan, Sara Vidal López, Yong Miao
Life of this patent
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Abstract
Disclosed are methods and compositions comprising glycopeptides obtained from gastrointestinal sources that have superior microbiota effects. Such compositions are advantageous for food stuff, including infant formulations.
Claims20
A composition comprising glycopeptides obtained from gastrointestinal tract mucins, wherein:
- a) the composition is obtained without subjecting the mucins or a partially purified fraction thereof to conditions or reagents that release oligosaccharides from glycoproteins or glycopeptides;
- b) the total oligosaccharide content of the composition is >15% (w/w);
- c) the free glycan content of the composition is <1% (w/w);
- d) the total glycoprotein content of the composition is 6% or less (w/w);
- and
- e) the composition comprises glycopeptide-bound oligosaccharides having each of the following general formulae:
- i. Hex1HexNAc1Fuc1;
- ii. Hex1HexNAc2;
- iii. Hex1HexNAc2Fuc1;
- iv. Hex1HexNAc2Fuc1Sul1;
- V. Hex1HexNAc3;
- vi. Hex2HexNAc2;
- vii. Hex2HexNAc2Fuc1
- viii. Hex2HexNAc2Fuc2;
- ix. Hex2HexNAc2Fuc2Sul1;
- x. Hex2HexNAc3;
- xi. Hex2HexNAc3Fuc1;
- xii. Hex2HexNAc4;
- xiii. Hex2HexNAc4Fuc1;
- and
- xiv. NeuAc1Hex1HexNAc2.
18 more elements
A composition comprising a mixture of free glycans and glycopeptides obtained from gastrointestinal tract mucins, wherein:
- a) the composition is obtained without subjecting the mucins or a partially purified fraction thereof to conditions or reagents that cause complete release of oligosaccharides from glycoproteins or glycopeptides;
- b) the total oligosaccharide content of the composition is >10% (w/w);
- c) the ratio of glycopeptides:free glycans is between 4:1 and 1:6 (w/w);
- d) the total glycoprotein content of the composition is 12% or less (w/w);
- and
- e) the composition comprises glycopeptide-bound oligosaccharides or free glycans having each of the following general formulae:
- i. Hex1HexNAc1Fuc1;
- ii. Hex1HexNAc2;
- iii. Hex1HexNAc2Fuc1;
- iv. Hex1HexNAc2Fuc1Sul1;
- V. Hex1HexNAc2Sul1;
- vi. Hex1HexNAc3;
- vii. Hex2HexNAc2Fuc1;
- viii. Hex2HexNAc2Fuc2;
- ix. Hex2HexNAc2Fuc2Sul1;
- X. Hex2HexNAc3;
- xi. Hex2HexNAc3Fuc1;
- xiii. Hex2HexNAc4;
- xiv. Hex2HexNAc4Fuc1;
- xv. NeuAc1Hex1HexNAc1;
- xvi. NeuAc1Hex1HexNAc1Fuc1;
- and
- xvii. NeuAc1Hex1HexNAc2.
20 more elements
Dependencies are inferred from the claim text.