Delivery of bacteria-derived outer membrane vesicles
AssigneeQuadram Institute Bioscience
InventorsSimon Carding, Regis Stentz
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Abstract
Pharmaceutical compositions and preparation including outer membrane vesicles (OMVs) and at least one pharmaceutically acceptable carrier wherein said OMVs are native OMVs produced by the Gram-negative commensal bacteria Bacteroides.
Claims13
A pharmaceutical preparation comprising outer membrane vesicles (OMVs), at least one additional pharmaceutically active component comprising a vaccine agent, and at least one pharmaceutically acceptable carrier, wherein said OMVs are native OMVs produced by the Gram-negative commensal bacteria Bacteroides, and wherein the OMVs are an adjuvant to reduce the number of doses and/or amount of vaccine agent required to elicit a protective immune response.
A pharmaceutical preparation according to any preceding claim wherein the species of Bacteroides producing the OMVs is B. acidifaciens, B. caccae, B. coprocola, B. coprosuis, B. eggerthii, B. finegoldii, B. fragilis, B. helcogenes, B. intestinalis, B. massiliensis, B. nordii, B. ovatus, B. stercoris, B. thetaiotaomicron, B. vulgatus, B. plebeius, B. uniformis, B. salyersai, B. pyogenes, B. goldsteinii, B. dorei and B. johnsonii and/or B. xylanisolvens.
Dependencies are inferred from the claim text.