Antibodies binding CD40 and uses thereof

An isolated monoclonal antibody or an antigen-binding portion thereof, capable of binding to CD40, comprising (i) a heavy chain variable region comprising a VH CDR1 region, a VH CDR2 region and a VH CDR3 region, and (ii) a light chain variable region comprising a VL CDR1 region, a VL CDR2 region and a VL CDR3 region, wherein the VH CDR1 region, the VH CDR2 region, the VH CDR3 region, the VL CDR1 region, the VL CDR2 region and the VL CDR3 region comprise amino acid sequences set forth in (1) SEQ ID NOs:

• 1, 4, 7, 10, 13 and 16, respectively;
• (2) SEQ ID NOs:
• 2, 5, 8, 11, 14 and 17, respectively;
• or (3) SEQ ID NOs:
• 3, 6, 9, 12, 15 and 18, respectively.