Reducing electrosensation whilst treating a subject using alternating electric fields by using larger cathodes and smaller anodes

A method of treating a target region of a subject's body with an electric field, the method comprising:

• applying a plurality of electrical pulses between at least one first electrode element and at least one second electrode element, wherein the at least one first electrode element and the at least one second electrode element are positioned on opposite sides of the target region, wherein the at least one first electrode element has a first collective area, wherein the at least one second electrode element has a second collective area that is at least twice as large as the first collective area, and wherein the plurality of electrical pulses has a polarity such that the at least one first electrode element operates as an anode and the at least one second electrode element operates as a cathode;
• and
• applying an electrical signal between the at least one first electrode element and the at least one second electrode element, wherein the electrical signal has a polarity such that the at least one first electrode element operates as a cathode and the at least one second electrode element operates as an anode, wherein the electrical signal charge-balances the plurality of electrical pulses, and wherein the electrical signal has an average amplitude,
• wherein the plurality of electrical pulses has an average amplitude that is at least twice the average amplitude of the electrical signal,
• wherein the plurality of electrical pulses has a pulse repetition rate between 50,000 and 1,000,000 pulses per second, and
• wherein the plurality of electrical pulses has a waveform that collectively resembles (i) a sequence of rectangular pulses with a 50% duty cycle, (ii) a rectified sinusoid, or (iii) an offset sinusoid.