Devices, systems and methods for cortical stimulation

A system for tracking a cortical region to be stimulated in a patient, the system comprising:

• at least one implantable device configured to be implanted in the head of the patient, the implantable device includes a plurality of recording electrodes for recording electrical signals from the cortical region, a plurality of stimulating electrodes for delivering stimulating electrical signals to at least part of the cortical region, a controller/processor for controlling the recording of the electrical signals from the cortical region and for controlling the delivering of the stimulating signals, a telemetry unit for wirelessly bi-directionally communicating with one or more external devices and a power source for energizing the implantable device,
• one or more external devices disposed outside the body of the patient, the one or more external devices includes at least one processor/controller configured for processing data and at least one telemetry unit for wirelessly bi-directionally communicating with the at least one implantable device,
• wherein the at least one implantable device and one or more external devices are in wireless communication there between and are programmed to perform the steps of,
• recording electrical cortical signals using the plurality of recording electrodes,
• processing the recorded electrical signals to compute spatial parameters representing the spatial distribution of the magnitude of at least one biomarker indicative of the cortical region to be stimulated,
• selecting from a look-up table (LUT) available in the system and including a plurality of simulated current spatial distribution data sets or datasets derived from the plurality of simulated current spatial distribution sets, a matched data set of stimulation parameters to be applied to the plurality of stimulating electrodes responsive to the spatial parameters representing the spatial distribution of the at least one biomarker computed in the step of processing, and
• applying to the cortical region stimulating electrical signals using the matched set of stimulation parameters selected in the step of selecting.