Back to results
US 12,473,554 B2Granted
MRNA treatment nanoparticles
AssigneeNutcracker Therapeutics, Inc.
InventorsSamuel Deutsch, Daniel Frimannsson, Nicole Fay, Colin McKinlay, Ole Haabeth
Life of this patent
Estimating the term…
Abstract
Provided herein are examples of mRNA treatment nanoparticles and methods of using them to treat a patient. An mRNA treatment nanoparticle may include one or more mRNAs encoding a tumor-specific antigen and an immunomodulatory agent; and a delivery vehicle molecule encapsulating the one or more mRNAs.
Claims12
A method comprising administering a therapeutic mRNA composition to a subject in need thereof, wherein the therapeutic mRNA composition comprises:
- a first mRNA scaffold comprising a first mRNA coding region encoding HPV16 E6 E7;
- a second mRNA scaffold comprising a second mRNA coding region encoding interleukin-12, wherein the second mRNA coding region has a nucleic acid sequence identical to SEQ ID NO:5;
- and
- a third mRNA scaffold comprising a third mRNA coding region encoding tumor necrosis factor superfamily member 14 (TNFSF14) wherein the third mRNA coding region has a nucleic acid sequence identical to SEQ ID NO:11, and
- wherein the first mRNA scaffold, the second mRNA scaffold and, the third mRNA scaffold are encapsulated in a delivery vehicle, wherein the delivery vehicle is selected from the group consisting of lipid nanoparticles, polymer-based nanoparticles, cationic lipids, ionizable lipids, amino-lipidated peptoids, amphipathic molecules/nanoparticles, and tertiary amino lipidated cationic peptoids.
2 more elements
Dependencies are inferred from the claim text.