Method of differentiating mesenchymal stem cells into cardiomyocytes
AssigneeChonnam National University Hospital
InventorsYoungkeun Ahn, Yong Sook Kim, Hye Jin Kang, Dong Im Cho
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Abstract
The present invention relates to a method of differentiating mesenchymal stem cells into cardiomyocytes. When the method of the present invention is used, cardiomyocytes may be obtained from mesenchymal stem cells with high efficiency. Therefore, the method of the present invention may be effectively used for treatment of heart diseases, such as heart failure, which require myocardial regeneration for treatment.
Claims5
A method of inducing differentiation of mesenchymal stem cells into cardiomyocytes, the method comprising treating adult mesenchymal stem cells by culturing the adult mesenchymal stem cells in a medium consisting of glucose-free basal culture medium and apicidin or in a medium consisting of glucose-free basal culture medium, apicidin and lactic acid, wherein apicidin induces differentiation of mesenchymal stem cells into cardiomyocytes,
- then washing the cultured cells to produce cardiomyocytes, wherein the culturing is performed for 4 to 27 hours and wherein the expression of cardiomyocyte-specific markers is increased in the cardiomyocytes compared to the adult mesenchymal stem cells.
Dependencies are inferred from the claim text.