Human placental tissue graft products, methods, and apparatuses

A method of producing a tissue graft, the method comprising:

• removing decidua cells and trophoblast cells from a fetal support tissue membrane;
• compressing the membrane;
• dehydrating the membrane;
• decontaminating the membrane;
• and
• mounting the membrane to a:
• flexible backing material to produce a formed tissue graft;
• wherein the native connective architecture between an amnion layer and a chorion layer of the membrane is maintained intact throughout the method,
• wherein the amnion layer is not decellularized,
• wherein the steps of compressing the membrane and dehydrating the membrane are performed simultaneously, and wherein the steps of compressing the membrane and dehydrating the membrane comprise positioning the membrane between a moisture-permeable support platform and a gas-impermeable sealing sheet, then depressurizing a chamber below the moisture-permeable support platform to pull a vacuum across the platform using a vacuum source,
• wherein the chamber, being below the moisture-permeable support platform, defines an opening at one end, the chamber being in fluid connection with the vacuum source, and
• wherein the moisture-permeable support platform covers the opening of the chamber and comprises a perforated rigid support layer and a moisture, liquid, and vapor permeable material layer, wherein the moisture, liquid, and vapor permeable material layer is positioned between the perforated rigid support layer and the membrane, and wherein the membrane is positioned between the gas-impermeable sealing sheet and the moisture, liquid, and vapor permeable material layer.