Methods and systems for improved collection of interstitial fluid
AssigneeGeorgia Tech Research Corporation
InventorsPradnya Samant, Chandana Kolluru, Mark R. Prausnitz
Life of this patent
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Abstract
Methods and devices of collecting ISF from skin. The methods may include inserting an array of microneedles into a patient's skin to form apertures in the patient's skin, facilitating ISF mobilization within the skin, and collecting ISF that flows from the apertures. The devices may include an array of microneedles extending from a backing structure. The devices also may include a collection matrix for collecting ISF and/or means for facilitating ISF mobilization.
Claims22
A method for collecting interstitial fluid (ISF) from a patient's skin, the method comprising:
- inserting a plurality of microneedles into the patient's skin at an insertion site to form a plurality of apertures in the patient's stratum corneum at the insertion site;
- inducing local edema to mobilize ISF within the patient's dermis at the insertion site;
- and
- collecting the ISF that flows from the apertures to a surface of the patient's skin at the insertion site,
- wherein the inducing the local edema within the patient's dermis is effective to increase a rate and/or a total amount of the ISF flowing from the apertures.
A device for collection of interstitial fluid (ISF) from a patient's skin, the device comprising:
- an array of solid microneedles configured for insertion across the stratum corneum of the patient's skin, each solid microneedle having an outer surface, an insertion tip end portion, and a base end portion;
- a backing structure from which the array of microneedles extends;
- an ISF collection matrix disposed in proximity to the base end portion of the microneedles to receive the ISF flowing along the outer surface toward the base end portion of the microneedles when the microneedles are inserted into the patient's skin;
- and
- a means for inducing local edema to mobilize ISF within the patient's dermis at an insertion site where the microneedles are inserted into the patient's skin.
A device for collection of interstitial fluid (ISF) from a patient's skin, the device comprising:
- an array of solid microneedles configured for insertion across the stratum corneum of the patient's skin, each solid microneedle having an outer surface, an insertion tip end portion, and a base end portion;
- a backing structure from which the array of microneedles extend;
- and
- a means for inducing local edema to mobilize ISF within the patient's dermis at an insertion site where the microneedles are inserted into the patient's skin.
A method for collecting interstitial fluid (ISF) from a human subject's skin, the method comprising:
- inserting a plurality of microneedles into the human subject's skin at an insertion site to form a plurality of apertures in the subject's stratum corneum at the insertion site;
- inducing local edema, without use of a bioactive agent, to mobilize ISF within the subject's dermis at the insertion site;
- and
- collecting the ISF that flows from the apertures to a surface of the human subject's skin,
- wherein the inducing the local edema within the subject's dermis is effective to increase a rate and/or a total amount of the ISF flowing from the apertures.
Dependencies are inferred from the claim text.