Vaccine comprising epitope of heat shock protein, and use thereof
AssigneeAston Sci. Co., Ltd.
InventorsKyong Hwa Park, Jinho Kang
Life of this patent
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Abstract
A vaccine containing an epitope of a heat shock protein 90 and uses thereof are disclosed. The epitope(s) of heat shock protein 90 has the amino acid sequence of SEQ ID NO: 1 and/or 2. A multi-epitope vaccine containing the epitope(s) and a method for treating or preventing cancer using the same are disclosed.
Claims13
A method for treating cancer in a subject in need thereof, comprising administering to the subject an effective amount of a composition, wherein the composition comprises a mixture of two different MHC class II-specific epitopes from a heat shock protein 90 (HSP90), wherein the two MHC class II-specific epitopes consist of the amino acid sequence of SEQ ID NO:
- 1 and the amino acid sequence of SEQ ID NO:
- 2, wherein the composition further comprises an anticancer adjuvant.
A method for treating cancer in a subject in need thereof, comprising administering to the subject an effective amount of a composition, wherein the composition comprises an isolated heat shock protein 90 (HSP90)-specific MHC class II epitope, wherein the epitope consists of a peptide selected from the group consisting of SEQ ID NOs:
- 1, 2, 5, 6, 7, 8, 9, 10, 11, 12, 13, and 14, wherein the composition further comprises an anticancer adjuvant.
A method for treating cancer in a subject in need thereof, comprising administering to the subject an effective amount of a composition, wherein the composition comprises nucleic acid molecule encoding an epitope consisting of a peptide selected from the group consisting of SEQ ID NOs:
- 1, 2, 5, 6, 7, 8, 9, 10, 11, 12, 13, and 14, wherein the composition further comprises an anticancer adjuvant.
Dependencies are inferred from the claim text.