Compositions and methods for induced tissue regeneration in mammalian species
AssigneeReverse BioEngineering, Inc.
InventorsMichael D. West, Karen Chapman, Hal Sternberg
Life of this patent
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Abstract
Aspects of the present invention include methods and compositions related to the modulation of molecules regulating the regenerative potential of cells and tissues in the embryonic state and the loss thereof in later fetal and adult stages of development. Said methods and compositions have uses in research in stem cell biology and in increasing regenerative potential in fetal and adult tissues otherwise incapable of regeneration.
Claims12
A method of increasing regenerative potential of mammalian connective tissue comprising administering to the one or more cells of the connective tissue a composition comprising a de-differentiation gene of OXTR and one or more de-differentiation genes selected from the group consisting of PCDHB2, PCDHB17, Nbla10527, RAB3IP, DLX1, DRD11P, FOXD1, LOC728755, AFF3, F2RL2, MN1, CBCAQH03 5′, LOC791120, SIX1, and WSB1,
- wherein the administering the composition to the one or more cells of the connective tissue is ex vivo or in vitro, and
- wherein one or more viral vectors comprise the OXTR gene and the one or more de-differentiation genes.
A kit for enhancing regenerative potential of mammalian connective tissue, wherein the kit comprises a composition comprising a de-differentiation gene of OXTR and one or more de-differentiation genes selected from the group consisting of PCDHB2, PCDHB17, Nbla10527, RAB3IP, DLX1, DRD11P, FOXD1, LOC728755, AFF3, F2RL2, MN1, CBCAQH03 5′, LOC791120, SIX1, and WSB1, one or more viral vectors comprise the OXTR gene and the one or more de-differentiation genes.
Dependencies are inferred from the claim text.