Vaccine and methods for detecting and preventing filariasis
AssigneeThe Board of Trustees of the University of Illinois
InventorRamaswamy Kalyanasundaram
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Abstract
The present invention is a multivalent immunogenic composition for immunizing an animal against filariasis. In some embodiments, the antigens of the multivalent immunogenic composition are protein-based, DNA-based, or a combination thereof. This invention also provides a method and kit for detecting a filarial nematode and determining vaccine efficacy.
Claims12
A multivalent immunogenic composition comprising an Abundant Larval Transcript antigen comprising SEQ ID NO:
- 122, a Small heat shock protein (HSP) 12.6 antigen comprising SEQ ID NO:81, and a Thioredoxin Peroxidase 2 antigen comprising SEQ ID NO:
- 83, in combination with two or more adjuvants.
A method for immunizing an animal against dirofilariasis comprising administering to a subject a multivalent immunogenic composition comprising two or more antigens, and in combination with two or more adjuvants, wherein said antigens are selected from an Abundant Larval Transcript antigen comprising SEQ ID NO:
- 121 or SEQ ID NO:122;
- a Small heat shock protein 12.6 antigen comprising SEQ ID NO:
- 81 or SEQ ID NO:
- 123;
- a Tetraspanin antigen comprising SEQ ID NO:
- 82;
- and a Thioredoxin Peroxidase 2 antigen comprising SEQ ID NO:
- 83 or SEQ ID NO:124 thereby immunizing the subject against dirofilariasis.
Dependencies are inferred from the claim text.