System and method to reduce tissue ororgan adhesion
AssigneeMedcura, Inc.
InventorMatthew B. Dowling
Life of this patent
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Abstract
A composition for providing a barrier between tissues and/or organs during or after a surgical procedure. The composition is a flowable solution of a hydrophobically-modified chitosan, wherein the hydrophobic modifications are selected to allow for adherence to tissue, cohesiveness of the composition upon application to tissue, and degradation over about two weeks after application. A method for providing a barrier between tissues and/or organs during or after a surgical procedure. Applying a hydrophobically-modified polymer to surfaces of tissues or organs in within a surgical site either before, during, and/or after a surgical procedure, wherein the modified polymer reduces adhesion between organs or tissues after surgery.
Claims14
A method for reducing adhesion between organs and tissues, comprising:
- applying a flowable solution of a hydrophobically-modified chitosan, wherein hydrophobic modifications of chitosan are selected to allow for adherence to tissue, cohesiveness of the composition upon application to tissue, and degradation after application;
- wherein the hydrophobically-modified chitosan is applied to surfaces of tissues or organs within a surgical site either before, during, and/or after a surgical procedure, wherein the hydrophobically-modified chitosan reduces adhesion between organs or tissues after surgery;
- and wherein the hydrophobically modified chitosan has about 10% to 50% of available functional groups occupied by hydrophobic groups, and wherein the hydrophobic groups comprise a C1 to C4 hydrocarbon group and a hydrocarbon group of greater than C6.
Dependencies are inferred from the claim text.