Thermally regulated transdermal drug delivery system
AssigneeMorningside Venture Investments Limited
InventorsPatrick H. Ruane, Jackie Joe Hancock, Anubhav Arora
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Abstract
Described herein are drug and other active agent transdermal delivery systems and devices to deliver active agents to skin or mucosa of a subject, and methods of delivering such active agents. In particular, systems, methods, and devices are described that control the concentration and timing of active agent delivery. Such systems or devices may include a transdermal membrane and a temperature control element for heating and/or cooling a portion of the transdermal delivery system to provide pulsatile active agent delivery through the transdermal membrane.
Claims32
A transdermal delivery system comprising:
- a transdermal membrane;
- a first active agent contained within a reservoir separate from and fluidically connected to the transdermal membrane, the transdermal membrane configured to control, in response to temperature, a flow of the first active agent from the reservoir to skin of a subject;
- and
- a temperature control element configured to cyclically heat to a first temperature and/or cool a portion of the transdermal delivery system so as to provide pulsatile delivery of the first active agent through the transdermal membrane,
- wherein the temperature control element is further configured to cyclically heat to a second temperature, different from the first temperature, the portion of the transdermal delivery system so as to provide pulsatile delivery of a second active agent through the transdermal membrane.
A method for transdermally delivering an active agent, comprising:
- cyclically heating to a first temperature and cooling a portion of a transdermal delivery system for a first amount of time;
- and
- after the first amount of time, cyclically heating to a second temperature and cooling the portion of the transdermal delivery system for a second amount of time,
- wherein the cyclic heating or cooling steps provide a pulsatile delivery of a first active agent from a reservoir based on the first temperature and a pulsatile deliver of a second active agent based on the second temperature, through a transdermal membrane of the transdermal delivery system to skin of a patient, wherein the transdermal membrane controls a flow of the first active agent and the second active agent in response to temperature.
A transdermal delivery system comprising:
- a transdermal membrane;
- a first active agent contained within a reservoir separate from and fluidically connected to the transdermal membrane, the transdermal membrane configured to control, in response to temperature, a flow of the active agent from the reservoir to skin of a subject;
- and
- a temperature control element configured to provide a first stimulus to a portion of the transdermal delivery system so as to provide pulsatile delivery of the first active agent through the transdermal membrane to the skin of the subject and provide a second stimulus to the portion of the transdermal delivery system so as to provide pulsatile delivery of a second active agent through the transdermal membrane, wherein the first stimulus is a first temperature and the second stimulus is a second temperature that is different than the first temperature.
Dependencies are inferred from the claim text.