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US 12,390,520 B2Granted
Vaccination in newborns and infants
AssigneeCure Vac SE
InventorsKarl-Josef Kallen, Thomas Kramps, Margit Schnee, Benjamin Petsch, Lothar Stitz
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AssigneeCure Vac SE
InventorsKarl-Josef Kallen, Thomas Kramps, Margit Schnee, Benjamin Petsch, Lothar Stitz
Estimating the term…
The present invention relates to vaccines comprising at least one mRNA encoding at least one antigen for use in the treatment of a disease in newborns and/or infants, preferably exhibiting an age of not more than 2 years, preferably of not more than 1 year, more preferably of not more than 9 months or even 6 months, wherein the treatment comprises vaccination of the newborn or infant and eliciting an immune response in said newborn or infant. The present invention is furthermore directed to kits and kits of parts comprising such a vaccine and/or its components and to methods applying such a vaccine or kit.
A method for stimulating a protective antigen specific immune response in a subject comprising, administering to the subject an effective amount of a composition comprising a purified mRNA encoding a respiratory syncytial virus (RSV) fusion protein, or an antigenic fragment thereof, said mRNA comprising a 5′ cap and a poly-A sequence, wherein said mRNA is complexed with a cationic or polycationic compound, wherein the composition is administered by injection and wherein the subject is no more than 2 years of age.
A method for stimulating a protective antigen specific immune response in a subject comprising, administering to the subject an effective amount of a composition comprising a purified mRNA encoding a respiratory syncytial virus (RSV) fusion protein, or an antigenic fragment thereof, said mRNA comprising:
Dependencies are inferred from the claim text.