Silica with ultra-fast dissolution properties
AssigneeSil'Innov Srcl
InventorsNicolas Mannu, Quentin Chevrot, Karine Croizet-Berger, Nicolas Rabasso, Ivan Coste-Maniere, Jullen Estager, Benoit Kartheuser
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Abstract
Mesoporous silicas with ultra-fast dissolution properties, compositions thereof methods of preparation thereof, and methods of use thereof. Mesoporous silicas with ultra-fast dissolution properties may be prepared by (i) forming a silica comprising an amphiphilic glycoside; and (ii) subsequently subjecting the silica comprising the amphiphilic glycoside to a heat-treatment above 400° C.
Claims15
A mesoporous silica prepared by:
- (i) forming a clogged mesoporous silica comprising an amphiphilic glycoside and a cationic load of alkali and/or earth alkaline metal ions,
- wherein step (i) further comprises (i-a) mixing a silica precursor in presence of said amphiphilic glycoside at a pH between 8 and 13, and (i-b) subsequently filtrating or drying said mixture,
- wherein said amphiphilic glycoside is present at 35% by weight to 80% by weight, based on the total weight of said silica precursor and said amphiphilic glycoside;
- and
- (ii) without washing said clogged mesoporous silica prior to further processing, subsequently subjecting said clogged mesoporous silica comprising said amphiphilic glycoside to a heat-treatment above 400° C.
An oral dosage form comprising a mesoporous silica prepared by:
- (i) forming a clogged mesoporous silica comprising an amphiphilic glycoside and a cationic load of alkali and/or earth alkaline metal ions,
- wherein step (i) further comprises (i-a) mixing a silica precursor in presence of said amphiphilic glycoside at a pH between 8 and 13, and (i-b) subsequently filtrating or drying said mixture,
- wherein said amphiphilic glycoside is present at 35% by weight to 80% by weight, based on the total weight of said silica precursor and said amphiphilic glycoside;
- and
- (ii) without washing said clogged mesoporous silica prior to further processing, subsequently subjecting said clogged mesoporous silica comprising said amphiphilic glycoside to a heat-treatment above 400° C.
A method for producing a mesoporous silica, comprising the steps of:
- (i) forming a clogged mesoporous silica comprising an amphiphilic glycoside and a cationic load of alkali and/or earth alkaline metal ions,
- wherein step (i) further comprises (i-a) mixing a silica precursor in presence of said amphiphilic glycoside at a pH between 8 and 13, and (i-b) subsequently filtrating or drying said mixture,
- wherein said amphiphilic glycoside is present at 35% by weight to 80% by weight, based on the total weight of said silica precursor and said amphiphilic glycoside;
- and
- (ii) without washing said clogged mesoporous silica prior to further processing, subsequently subjecting said clogged mesoporous silica comprising said amphiphilic glycoside to a heat-treatment above 400° C.
Dependencies are inferred from the claim text.