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AssigneeMiltenyi Biotec GmbH
InventorsThomas Schaser, Johann-Christoph Dettmann, Martin Meyer, Ian Johnston
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The present invention provides the use of a packaging cell line for the production of VSV-G pseudotyped retroviral vector particles or virus like particles thereof, wherein said packaging cell line is negative for Low-Density Lipoprotein Receptor (LDLR), optionally said packaging cell line stably expresses VSV-G. A method for producing said VSV-G pseudotyped retroviral vector particles or virus like particles thereof is disclosed as well as said particles obtained by said method.
A method for producing vesicular stomatitis virus envelope protein (VSV-G) pseudotyped vectors that contain a Ψ-positive nucleic acid encoding one or more transgene products or virus-like particles thereof containing said transgene product(s),
A method for producing vesicular stomatitis virus G envelope protein (VSV-G) pseudotyped vectors that contain a Ψ-positive nucleic acid encoding one or more transgene products or virus-like particles thereof containing said transgene product(s),
A combination configured for producing vesicular stomatitis virus G envelope protein (VSV-G) pseudotyped vectors containing a nucleic acid that encodes one or more transgene products, the combination comprising:
A combination configured for producing vesicular stomatitis virus G envelope protein (VSV-G) pseudotyped virus-like particles containing one or more transgene products, the combination comprising:
Dependencies are inferred from the claim text.