Oral dosage form containing theobromine-free cocoa
AssigneeLTS Lohmann Therapie-Systeme AG
InventorsThomas Hille, Gabriel Wauer, Frank Seibertz
Life of this patent
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Abstract
Disclosed are stable dosage forms for oral administration of active pharmaceutical ingredients in which any unpleasant taste sensation, caused by release of the active pharmaceutical ingredient and/or of the excipients in the oral and pharyngeal cavity of the patient, is masked by the use of theobromine-free cocoa.
Claims14
An oral dosage form in the form of an oral film which, when administered, releases an active pharmaceutical ingredient into the oral and pharyngeal cavity, said oral dosage form containing:
- a) at least one active pharmaceutical ingredient;
- b) at least one excipient;
- and
- c) theobromine-free cocoa, wherein the oral dosage form contains at most 10% by weight of theobromine-free cocoa.
An oral dosage form in the form of an oral film which, when administered, releases an active pharmaceutical ingredient into the oral and pharyngeal cavity, said oral dosage form containing
- a) at least one active pharmaceutical ingredient selected from the group consisting of acetaminophen, adlupulon, agomelatine, albuterol, alverine, amitriptyline, amphetamine sulfate, amygdalin D, apomorphine, artemisinin, aspirin, atorvastatin, atropine, azathioprine, barbiturates, amobarbital, cyclobarbital, pentobarbital, phenobarbital, benzaldehyde, benzamine, benzoin, brucine, caffeine, caprolactam, carisoprodol, cascarillin, catechin, cetirizine, quinidine, quinine, chlordiazepoxide, chlorhexidine, chloroquine, chlorpheniramine maleate, chlorpromazine, cinnamedrine, cinchonine, clarithromycin, clobutinol, clonixin, codamine, codeine, colchicine, cycloheximide, deferiprone, demerol, dexamethasone, dextromethorphan, diclofenac, diphenhydramine, diphenylhydantoin, dorzolamide, doxepin, doxylamine, enalapril, epinephrine, erythromycin, falcarindiol, famotidine, fentanyl citrate, glimepiride, guaifenesin, haloperidol, hydrocortisone, ibuprofen, lidocaine, lincomycin, lomotil, loperamide, lupolone, methacholine, methadone, 6-methyl-2-thiouracil, miconazole, morphine hydrochloride, sodium benzoate, neostigmine, nicotine, omeprazole, ondansetron, orphenadrine, pantoprazole, papaverine, pemirolast, penicillin, peroxide, phenacetin, phenothiazine, phenytoin, prednisolone, prednisolone sodium phosphate, prednisone, propylthiouracil, pseudoephedrine hydrochloride, rizatriptan, salicylamide, salicylic acid, salsalate, sildenafil citrate, streptomycin, sulfonamide, terfenadine, topiramate, tramadol, trapidil, trimethadione, trimethoprim, valpromide, vitamins, thiamine, warfarin, and salts thereof, arbutin, coumarin, cucurbitacin B, ginkgolide A, ginkgolide B, ginkgolide C, harman, helenalin, helicin, humulone, lupinine, noscapine, parthenolide, picrotoxinin, taurine, acesulfame-K, magnesium sulfate and saccharin;
- b) at least one excipient;
- and
- c) theobromine-free cocoa, wherein the oral dosage form contains at most 15% by weight of theobromine-free cocoa.
Dependencies are inferred from the claim text.