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US 12,239,718 B2Granted
Synthetic cellular signaling pathways and uses thereof
AssigneeTrustees of Boston University
InventorsMark W. Grinstaff, Jack R. Kirsch, Amanda K. Williamson, Brett Tingley
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Abstract
The disclosure relates generally to methods and compositions for generation or enhancement of partial or complete cellular signaling pathways.
Claims16
A nucleic acid combination comprising:
- (i) a first nucleic acid molecule encoding a ligand;
- and
- (ii) a second nucleic acid molecule encoding a target molecule, wherein the target is a cognate receptor of the ligand or an inhibitor of a suppressor of the ligand,
- wherein one of the ligand and the target molecule is translated via a cap-dependent manner and the other of the ligand and the target molecule is translated via a cap-independent manner,
- wherein the first and second nucleic acid are covalently linked to form a nucleic acid encoding both the ligand and the target molecule,
- wherein the ligand is a protein, a protein fragment, a fusion protein, and wherein the target molecule is a protein or a polypeptide.
3 more elements
Dependencies are inferred from the claim text.