Active agent depots formed in situ
AssigneeSurModics, Inc.
InventorJoram Slager
Life of this patent
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Abstract
Embodiments herein relate to active agent depots formed in situ and related methods. In various embodiments, a method of forming an active agent depot in situ is included. The method can include contacting a composition with a vessel wall, wherein the composition includes an active agent and a fibrin promoting vessel wall transfer agent wherein the ratio of active agent to fibrin promoting vessel wall transfer agent (wt./wt.) is at least 5:1. The method also includes transferring the composition from a device surface to the vessel wall surface. The method also includes forming a fibrin matrix around the composition. Other embodiments are also included herein.
Claims15
A method of forming an active agent releasing depot in situ comprising
- contacting a layer of a composition with a vessel wall;
- wherein the composition comprises
- a first gradient layer comprising a first active agent;
- a second gradient layer comprising the first active agent and a second active agent, wherein the first gradient layer is disposed over the second gradient layer;
- and
- a third gradient layer comprising the first active agent and a third active agent, wherein the second gradient layer is disposed over the third gradient layer;
- wherein the first gradient layer, the second gradient layer, and the third gradient layer all comprise a fibrin promoting vessel wall transfer agent;
- wherein the composition has an increasing concentration gradient of the first active agent from the first gradient layer to the third gradient layer;
- transferring the layer of the composition from a device surface to the vessel wall surface;
- and
- forming an initial fibrin matrix around the composition.
Dependencies are inferred from the claim text.