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US 12,222,355 B2Granted
Therapeutic antibodies against ROR-1 protein and methods for use of same
AssigneeThe Regents of the University of California
InventorsThomas J. Kipps, George F. Widhopf, II, Bing Cui
Life of this patent
Estimating the term…
Abstract
Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
Claims9
An isolated anti-ROR1 antibody comprising a humanized heavy chain variable region and a humanized light chain variable region, wherein:
- a) said heavy chain variable region comprises complementarity determining regions corresponding to amino acids 26 to 33, 51 to 57, and 96 to 106 of SEQ ID NO:
- 14, and said light chain variable region comprises complementarity determining regions corresponding to amino acids 26 to 31, 49 to 51, and 88 to 96 of SEQ ID NO:
- 16;
- b) said heavy chain variable region comprises complementarity determining regions corresponding to amino acids 26 to 33, 51 to 58, and 97 to 108 of SEQ ID NO:
- 6, and said light chain variable region comprises complementarity determining regions corresponding to amino acids 27 to 32, 50 to 52, and 89 to 97 of SEQ ID NO:
- 8;
- or
- c) said heavy chain variable region comprises complementarity determining regions corresponding to amino acids 26 to 33, 51 to 57, and 96 to 107 of SEQ ID NO:
- 18, and said light chain variable region comprises complementarity determining regions corresponding to amino acids 27 to 32, 50 to 52, and 89 to 97 of SEQ ID NO:
- 20.
7 more elements
Dependencies are inferred from the claim text.