Magnesium ion selective membranes
AssigneeSiemens Healthcare Diagnostics Inc.
InventorsJohn Benco, Robert Bergquist
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Abstract
The present invention is directed to membranes, sensors, systems and process for the detection of magnesium ions in protein-containing samples. The novel membranes, sensors, systems, and processes are based upon the discovery that the lipophilicity of the plasticizer (or blend of plasticizers) utilized in the formulation of magnesium ion selective membranes for clinical use is inversely proportional to the sensitivity of the plasticizer(s) and directly proportional to the use life thereof.
Claims19
A magnesium ion selective membrane that has magnesium selectivity over calcium, the magnesium ion selective membrane comprising:
- a polymer material;
- a magnesium-selective material comprising a single ionophore, wherein the ionophore comprises a triamide compound;
- and
- a blend of two or more plasticizers, wherein at least one plasticizer comprises a measured log P value of greater than about 5.8 and less than about 12.8, wherein each plasticizer comprises a nitrophenyl group and hydrophobic chain extending therefrom with a structure of:
- wherein R1 comprises a straight-chain alkyl group having 10 to 14 carbons or comprises a 12-(4-ethyl-phenyl)-dodecyl group.
A magnesium ion selective membrane that has magnesium selectivity over calcium, the magnesium ion selective membrane comprising:
- a polymer material;
- a magnesium-selective material comprising a single ionophore, wherein the ionophore comprises a triamide compound;
- and
- a plasticizer comprising a measured log P value of about 8, wherein the plasticizer comprises a nitrophenyl group and hydrophobic chain extending therefrom with a structure of:
- wherein R1 comprises a straight-chain alkyl group having 10 to 14 carbons or comprises a 12-(4-ethyl-phenyl)-dodecyl group.
Dependencies are inferred from the claim text.