Method, apparatus, and computer-readable medium for efficiently optimizing a phenotype with a combination of a generative and a predictive model

A apparatus executed by one or more computing devices for efficiently optimizing a phenotype with a combination of a generative and a predictive model, the apparatus comprising:

• one or more processors;
• and
• one or more memories operatively coupled to at least one of the one or more processors and having instructions stored thereon that, when executed by at least one of the one or more processors, cause at least one of the one or more processors to:
• generate a plurality of new genotype vectors with a genotype generation model, the genotype generation model being trained based at least in part on a plurality of sample genotype vectors;
• apply a phenotype prediction model to the plurality of new genotype vectors to generate a plurality of scores, the phenotype prediction model being configured to predict one or more phenotypic attributes of the new genotype vectors;
• determine a plurality of result genotypes based at least in part on a ranking of the plurality of new genotype vectors according to the plurality of scores;
• and
• generate a result based at least in part on the plurality of result genotypes, the result indicating one or more genetic constructs for testing.

At least one non-transitory computer-readable medium storing computer-readable instructions for efficiently optimizing a phenotype with a combination of a generative and a predictive model that, when executed by one or more computing devices, cause at least one of the one or more computing devices to:

• generate a plurality of new genotype vectors with a genotype generation model, the genotype generation model being trained based at least in part on a plurality of sample genotype vectors;
• apply a phenotype prediction model to the plurality of new genotype vectors to generate a plurality of scores, the phenotype prediction model being configured to predict one or more phenotypic attributes of the new genotype vectors;
• determine a plurality of result genotypes based at least in part on a ranking of the plurality of new genotype vectors according to the plurality of scores;
• and
• generate a result based at least in part on the plurality of result genotypes, the result indicating one or more genetic constructs for testing.