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US 12,215,387 B2Granted
Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment
AssigneeNovartis AG
InventorsDominik Feuerbach, Baltazar Gomez-Mancilla, Yunsheng He, Donald Johns, Cristina Lopez-Lopez, Kevin Hall McAllister, Nicole Pezous, Lisa Sandford, Markus Weiss
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Abstract
The invention provides methods for predicting therapeutic responsiveness of a subject suffering from cognitive impairments or dysfunctions, psychotic and/or neurodegenerative disorders to an alpha 7 nicotinic acetylcholine receptor activator treatment.
Claims20
A method for treating an individual suffering from schizophrenia, the method comprising:
- administering a therapeutically effective amount of an alpha 7 nicotinic acetylcholine receptor activator to the individual, wherein the individual is selected by:
- determining that a genotype of the individual at the genetic locus of the human cytochrome P450, family 1, sub-family A, polypeptide 2 (CYP1A2) gene includes:
- (i) a homozygous SNP genotype of rs2069514-A/A;
- or
- (ii) a heterozygous SNP genotype of rs2069514-A/G;
- or
- (iii) a SNP forming a haplotype with said SNP genotypes or a SNP in the same linkage disequilibrium with said SNP genotypes.
4 more elements
A method for treating an individual suffering from diminished cognitive skills, the method comprising:
- administering a therapeutically effective amount of (R)-3-(6-p-tolyl-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane to the individual, wherein the individual is selected by:
- determining that a genotype of the individual at the genetic locus of the human cytochrome P450, family 1, sub-family A, polypeptide 2 (CYP1A2) gene includes:
- (i) a homozygous SNP genotype of rs2069514-A/A;
- or
- (ii) a heterozygous SNP genotype of rs2069514-A/G;
- or
- (iii) a SNP forming a haplotype with said SNP genotypes or a SNP in the same linkage disequilibrium with said SNP genotypes.
4 more elements
Dependencies are inferred from the claim text.