System and method for providing biology-based anti-tamper

An anti-tamper system installed at a portion of an object and configured to detect a tampering activity to the object, comprising:

• one or more biological anti-tamper mediums comprising:
• a biological member formed on the object;
• and
• a medium that is disposed at the portion of the object to form a coating of the biological member, contains the biological member and holds the biological member in contact with the object, wherein:
• the biological member includes at least one biological material that is engineered to change a state when exposed to one or more stimuli and is engineered such that the change of the state is detectable,
• wherein the biological material includes a ribonucleic acid (RNA) strand including at least three fixed domains and a plurality of variable domains,
• wherein among the at least three fixed domains two fixed domains are located closer to each other within the RNA strand relative to the third fixed domain, thereby rendering sections of nucleic acids of varying size located between the fixed domains,
• wherein exposure of the RNA to one or more stimuli can degrade one or more sections of nucleic acids located between the fixed domains into one or more strands of varying size thereby showing the extent of degradation of the RNA;
• and
• the plurality of the variable domains include barcoded variable domains, and
• the barcoded variable domains are barcoded differently from each other.