Adeno-associated virus (AAV) delivery of anti-FAM19A5 antibodies
AssigneesNeuracle Science Co., Ltd., Neuracle Genetics Inc.
InventorsJong-Mook Kim, Dong Sik Kim, Juwon Shim, Soon-gu Kwon
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Abstract
The present disclosure provides adeno-associated vims (AAV) vectors and uses thereof. In certain embodiments, the AAV vectors comprise a nucleic acid that encodes an antagonist against a family with sequence similarity 19, member A5 (FAM19A5) protein, e.g., anti-FAM19A5 antibody, e.g., anti-FAM19A5 scFv.
Claims20
An adeno-associated virus (AAV) vector comprising a nucleic acid that encodes an antibody, or an antigen-binding portion thereof, which specifically binds to a family with sequence similarity 19, member A5 (FAM19A5) protein (anti-FAM19A5 antibody), wherein the anti-FAM19A5 antibody comprises a heavy chain CDR1, CDR2, and CDR3 and a light chain CDR1, CDR2, and CDR3, and wherein:
- (i) the heavy chain CDR3 comprises the amino acid sequence set forth in SEQ ID NO:
- 16;
- (ii) the heavy chain CDR1 comprises the amino acid sequence set forth in SEQ ID NO:
- 212;
- (iii) the heavy chain CDR2 comprises the amino acid sequence set forth in SEQ ID NO:
- 213;
- (iv) the light chain CDR1 comprises the amino acid sequence set forth in SEQ ID NO:
- 222;
- (v) the light chain CDR2 comprises the amino acid sequence set forth in SEQ ID NO:
- 225;
- and
- (vi) the light chain CDR3 comprises the amino acid sequence set forth in SEQ ID NO:
- 224.
An adeno-associated virus (AAV) vector comprising a nucleic acid that encodes an antibody, or an antigen-binding portion thereof, which specifically binds to a family with sequence similarity 19, member A5 (FAM19A5) protein (anti-FAM19A5 antibody), wherein the nucleic acid comprises the nucleotide sequence set forth in SEQ ID NO:
- 204, or SEQ ID NO:
- 301.
An adeno-associated virus (AAV) vector comprising a nucleic acid that encodes an antibody, or an antigen-binding portion thereof, which specifically binds to a family with sequence similarity 19, member A5 (FAM19A5) protein (anti-FAM19A5 antibody), wherein the scFv comprises the amino acid sequence set forth in SEQ ID NO:
- 201 or SEQ ID NO:
- 256.
Dependencies are inferred from the claim text.