Immunotoxins with albumin binding domain

A nucleic acid comprising a nucleotide sequence encoding a molecule, the molecule comprising a sequence of Formula (I):

• TM-R1k-ABD-R2m-FCS-R3p-R4q-PE functional domain III (Formula I)
• wherein:
• TM is a targeting moiety;
• R1 is 1 to 20 amino acid residues;
• k, m, p, and q are, independently, 0 or 1;
• ABD is an albumin binding domain and comprises the amino acid sequence of SEQ ID NO:
• 2;
• R2 is 1 to 20 amino acid residues;
• FCS is a furin cleavage sequence of amino acid residues, which sequence is cleavable by furin and has an amino end and a carboxyl end;
• R3 is 1 to 20 amino acid residues;
• R4 is 1 or more contiguous residues of residues 365-394 of SEQ ID NO:
• 1;
• and
• PE functional domain III is residues 395-613 of Pseudomonas exotoxin A (PE) SEQ ID NO:
• 1,
• wherein the molecule has a deletion of amino acid residues 253-273 and 285-364 as defined by SEQ ID NO:
• 1;
• and
• wherein the molecule optionally has (i) a substitution of one or more amino acid residues within one or more T-cell epitopes, (ii) a substitution of one or more amino acid residues within one or more B cell epitopes, (iii) a deletion of one or more contiguous amino acid residues of residues 1-252 as defined by SEQ ID NO:1;
• or (iv) a combination of any of (i)-(iii).