BAFF-R targeted chimeric antigen receptor-modified T-cells and uses thereof
AssigneesCity of Hope, Board of Regents, The University of Texas System
InventorsHong Qin, Larry W. Kwak
Life of this patent
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Abstract
Provided herein are T cells expressing a chimeric antigen receptor (CAR) targeted to B cell activating factor receptor (BAFF-R). The CAR targeted to BAFF-R (BAFF-R CAR) described herein includes a domain that binds BAFF-R. Methods of making and using the BAFF-R CAR are also provided.
Claims17
A nucleic acid molecule encoding a chimeric antigen receptor, wherein the chimeric antigen receptor comprises an scFv targeted to BAFF-R, wherein the scFv includes a light chain variable region and a heavy chain variable region, wherein the light chain variable region includes CDR L1 (SEQ ID NO:1), CDR L2 (SEQ ID NO:2) and CDR L3 (SEQ ID NO:
- 3);
- and the heavy chain variable region includes CDR H1 (SEQ ID NO:4), CDR H2 (SEQ ID NO:5), and CDR H3 (SEQ ID NO:6);
- a CD4 transmembrane domain or variant thereof having 1-5 amino acid modifications;
- a costimulatory domain comprising a 4-1BB costimulatory domain or a variant thereof having 1-5 amino acid modifications;
- and CD3ζ signaling domain or a variant thereof having 1-5 amino acid modifications.
Dependencies are inferred from the claim text.