Compositions and methods for targeting γδ T cells with chimeric antigen receptors
AssigneeThe Trustees of the University of Pennsylvania
InventorsAimee S. Payne, Christoph T. Ellebrecht
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Abstract
The invention includes compositions comprising a chimeric antigen receptor (CAR) specific for an GD T Cell receptor (anti-GD TCR CAR), vectors comprising the same, compositions comprising anti-GD TCR CAR vectors packaged in viral particles, and recombinant T cells or other effector cells comprising the anti-GD TCR CAR of the invention. The invention also includes methods of making a genetically modified T cell expressing an anti-GD TCR CAR wherein the expressed CAR comprises an extracellular domain that binds to GD T cells or to cells expressing a GD TCR.
Claims22
An isolated nucleic acid comprising a nucleic acid sequence encoding an anti-GD TCR CAR comprising the amino acid sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.