Anti-SLC34A2 monoclonal antibodies and uses thereof
AssigneeLanova Medicines Development Co., Ltd.
InventorsRunsheng Li, Wentao Huang, Yifan Li
Life of this patent
Estimating the term…
Abstract
Provided are antibodies or fragment thereof having binding specificity to the human solute carrier 34 A2 (SLC34A2) protein. These antibodies are capable of binding to SLC34A2 at high affinity and can mediate antibody-dependent cellular cytotoxicity (ADCC) and effectively induce endocytosis. Also provided are methods and uses for treating cancers.
Claims17
An antibody or fragment thereof having binding specificity to a human solute carrier 34 A2 (SLC34A2) protein, wherein the antibody or fragment thereof comprises a heavy chain variable region comprising heavy chain complementarity determining regions CDRH1, CDRH2, and CDRH3 and a light chain variable region light chain comprising complementarity determining regions CDRL1, CDRL2, and CDRL3, and wherein:
- (a) the CDRH1 comprises the amino acid sequence of SEQ ID NO:
- 51,
- the CDRH2 comprises the amino acid sequence of SEQ ID NO:
- 52 or 57,
- the CDRH3 comprises the amino acid sequence of SEQ ID NO:
- 53,
- the CDRL1 comprises the amino acid sequence of SEQ ID NO:
- 54,
- the CDRL2 comprises the amino acid sequence of SEQ ID NO:
- 55, and
- the CDRL3 comprises the amino acid sequence of SEQ ID NO:
- 56,
- (b) the CDRH1 comprises the amino acid sequence of SEQ ID NO:
- 66,
- the CDRH2 comprises the amino acid sequence of SEQ ID NO:
- 67 or 72,
- the CDRH3 comprises the amino acid sequence of SEQ ID NO:
- 68,
- the CDRL1 comprises the amino acid sequence of SEQ ID NO:
- 69,
- the CDRL2 comprises the amino acid sequence of SEQ ID NO:
- 70, and
- the CDRL3 comprises the amino acid sequence of SEQ ID NO:
- 71,
- (c) the CDRH1 comprises the amino acid sequence of SEQ ID NO:
- 81,
- the CDRH2 comprises the amino acid sequence of SEQ ID NO:
- 82 or 87,
- the CDRH3 comprises the amino acid sequence of SEQ ID NO:
- 83,
- the CDRL1 comprises the amino acid sequence of SEQ ID NO:
- 84,
- the CDRL2 comprises the amino acid sequence of SEQ ID NO:
- 85, and
- the CDRL3 comprises the amino acid sequence of SEQ ID NO:
- 86, or
- (d) the CDRH1 comprises the amino acid sequence of SEQ ID NO:
- 96,
- the CDRH2 comprises the amino acid sequence of SEQ ID NO:
- 97 or 102,
- the CDRH3 comprises the amino acid sequence of SEQ ID NO:
- 98 or 103,
- the CDRL1 comprises the amino acid sequence of SEQ ID NO:
- 99,
- the CDRL2 comprises the amino acid sequence of SEQ ID NO:
- 100, and
- the CDRL3 comprises the amino acid sequence of SEQ ID NO:
- 101.
Dependencies are inferred from the claim text.