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US 12,215,149 B2Granted
Anti-MS4A6A antibodies and methods of use thereof
AssigneeAlector LLC
InventorsPhilip Kong, Herve Rhinn, Tina Schwabe, Angie Yee, Arnon Rosenthal
Life of this patent
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Abstract
The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a MS4A6A polypeptide, e g., a mammalian MS4A6A or human MS4A6A, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
Claims19
An isolated antibody that binds to human MS4A6A, wherein the antibody comprises a heavy chain variable region and a light chain variable region, wherein:
- (i) the heavy chain variable region comprises
- an HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 14;
- an HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 29;
- an HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 43;
- and
- the light chain variable region comprises:
- an HVR-L1 comprising the amino acid sequence of SEQ ID NO:
- 57;
- an HVR-L2 comprising the amino acid sequence of SEQ ID NO:
- 73;
- and
- an HVR-L3 comprising the amino acid sequence of SEQ ID NO:
- 84;
- or
- (ii) the heavy chain variable region comprises:
- an HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 11;
- an HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 24;
- an HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 39;
- and
- the light chain variable region comprises:
- an HVR-L1 comprising the amino acid sequence of SEQ ID NO:
- 53;
- an HVR-L2 comprising the amino acid sequence of SEQ ID NO:
- 68;
- and
- an HVR-L3 comprising the amino acid sequence of SEQ ID NO:
- 84.
30 more elements
Dependencies are inferred from the claim text.