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US 12,215,130 B2Granted
Cytokine-albumin binding moiety fusion proteins and uses thereof
AssigneeAnwita Biosciences, Inc.
InventorsZiyang Zhong, Fan Ye, Matthew Siegel, Jianing Huang, Eric Liao, Ella Li
Life of this patent
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Abstract
The present application provides fusion proteins that comprise a cytokine fused to an albumin binding moiety. The fusion proteins may further comprise an antigen binding moiety such as a therapeutic antibody. The present application also provides methods of making and using the fusion proteins. The present application also provides methods of treatment comprises administering a fusion protein comprising a cytokine fused to a half-life extending domain and a second agent.
Claims18
A fusion protein comprising:
- a) an IL-21 and b) an albumin binding moiety that is a single domain antibody (sdAb) comprising:
- (1) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 69;
- a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 70;
- and
- a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 71;
- (2) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 72;
- a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 73;
- and
- a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 74;
- (3) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 75;
- a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 76;
- and
- a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 77;
- (4) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 78;
- a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 79;
- and
- a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 80;
- (5) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 81;
- a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 82;
- and
- a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 83;
- (6) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 84;
- a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 85;
- and
- a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 86;
- (7) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 87;
- a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 88;
- and
- a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 89;
- (8) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 90;
- a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 91;
- and
- a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 92;
- or
- (9) a CDR1 comprising the amino acid sequence of SEQ ID NO:
- 93;
- a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 94;
- and
- a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 95.
62 more elements
Dependencies are inferred from the claim text.