Cationic steroidal antimicrobial compounds with endogenous groups

A cationic steroidal antimicrobial (CSA) compound having a structure of Formula III, or a salt thereof:

• where,
• R3, R7, and R12 are independently selected from the group consisting of:
• R22R23N—R21—(C═O)—O—, and
• R22R23N—R21—(C═O)—N—
• where R21 is substituted or unsubstituted alkyl and R22 and R23 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, and aryl;
• and
• R18 has a structure selected from the group consisting of:
• —R19—(C═O)—O—R20,
• —R19—O—(C═O)—R20, and
• —R19—(C═O)—NX—R20,
• where R19 is an alkyl, R20 is a natural or endogenous terpenyl group, and X is selected from hydrogen, alkyl, alkenyl, alkynyl, or aryl, wherein the natural or endogenous terpenyl group is formed from a terpene selected from the group consisting of:
• one or more of:
• one or more of:
• one or more of:

A cationic steroidal antimicrobial (CSA) compound having a structure of Formula III, or a salt thereof:

• where,
• R3, R7, and R12 are each an amino acid attached to the sterol backbone by an ester linkage;
• and
• R18 has a structure selected from the group consisting of:
• —R19—(C═O)—O—R20, and
• —R19—O—(C═O)—R20,
• where R19 is a C5 alkyl, R20 is a natural or endogenous terpenyl group, and X is selected from hydrogen, alkyl, alkenyl, alkynyl, or aryl, wherein the natural or endogenous terpenyl group is formed from a terpene selected from the group consisting of:
• one or more of:
• one or more of:
• one or more of: