Arginase inhibitors and methods of use

A compound of Formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• W is selected from the group consisting of straight or branched (C2-C5) alkylene, wherein one or more —CH2— groups in W are optionally and independently replaced with a moiety selected from the group consisting of —O—, —S— or —NH—;
• V is selected from the group consisting of a bond, O, S, CR6R7 or NR8;
• X is selected from the group consisting of a bond, O, S, CR9R10 or NR11;
• Y is selected from the group consisting of a bond, O, S, CR12R13 or NR14,
• is selected from the group consisting of a bond, O, S, CR15R16 or NR17, R1 is selected from the group consisting of hydrogen, —C3-C6cycloalkyl or —C1-C6alkyl or, taken with R2 forms a C3-C8cycloalkyl, wherein the C3-C8cycloalkyl is optionally substituted with one to four substituents selected from the group consisting of halogen, —C1-C6alkyl or —OH;
• R2 is selected from the group consisting of hydrogen, —C3-C6cycloalkyl or —C1-C6alkyl or, taken with R1 forms a C3-C8cycloalkyl, wherein the C3-C8cycloalkyl is optionally substituted with one to four substituents selected from the group consisting of halogen, —C1-C6alkyl or —OH;
• R3 is —COOH;
• R4 is hydrogen, halogen, —C3-C6cycloalkyl, —C1-C6alkyl, —C1-C6alkylOH, —COOH, —C1-C6alkylN(R18)(R19), —C1-C6alkylheteroaryl, heteroaryl, —C1-C6alkoxy or —COOC1-C6alkyl;
• R5 is selected from the group consisting of hydrogen, halogen, —CN, —OH, —C1-C6alkylCOOH, —COOH, —C3-C6cycloalkyl, —C1-C6alkyl, -haloC1-C6alkyl, —C1-C6alkylOH, —C1-C6alkylheteroaryl, —CON(R18)(R19), —N(R18)(R19) or —C1-C6alkylN(R18)(R19);
• R6 is selected from the group consisting of hydrogen, halogen, —OH, C1-C6alkylOH, —C3-C6cycloalkyl, —C1-C6alkyl, -haloC1-C6alkyl, —COOH, —N(R18)(R19), —C1-C6alkylheteroaryl, —C1-C6alkylN(R18)(R19), —C1-C6alkoxy or —COOC1-C6alkyl;
• R7 is selected from the group consisting of hydrogen, halogen, —OH, —C1-C6alkylOH, —C3-C6cycloalkyl, —C1-C6alkyl, —haloC1-C6alkyl, —COOH, —N(R18)(R19), —C1-C6alkylheteroaryl, —C1-C6alkylN(R18)(R19), —C1-C6alkoxy or —COOC1-C6alkyl;
• R8 is selected from the group consisting of hydrogen, —C3-C6cycloalkyl, —C1-C6alkyl, —C1-C6alkylheteroaryl, or —C1-C6alkylN(R18)(R19);
• R9 is selected from the group consisting of hydrogen, halogen, —OH, —C1-C6alkylOH, —C3-C6cycloalkyl, —C1-C6alkyl, -haloC1-C6alkyl, —COOH, —N(R18)(R19), —C1-C6alkylheteroaryl, —C1-C6alkylN(R18)(R19), —C1-C6alkoxy or —COOC1-C6alkyl;
• R10 is selected from the group consisting of hydrogen, halogen, —OH, —C1-C6alkylOH, —C3-C6cycloalkyl, —C1-C6alkyl, —haloC1-C6alkyl, —COOH, —N(R18)(R19), —C1-C6alkylheteroaryl, —C1-C6alkylN(R18)(R19), —C1-C6alkoxy or —COOC1-C6alkyl;
• R11 is selected from the group consisting of hydrogen, —C3-C6cycloalkyl, —C1-C6alkyl, —C1-C6alkylheteroaryl, or —C1-C6alkylN(R18)(R19);
• R12 is selected from the group consisting of hydrogen, halogen, —OH, —C1-C6alkylOH, —C3-C6cycloalkyl, —C1-C6alkyl, —haloC1-C6alkyl, —COOH, —N(R18)(R19), —C1-C6alkylheteroaryl, —C1-C6alkylN(R18)(R19), —C1-C6alkoxy or —COOC1-C6alkyl;
• R13 is selected from the group consisting of hydrogen, halogen, —OH, —C1-C6alkylOH, —C3-C6cycloalkyl, —C1-C6alkyl, —haloC1-C6alkyl, —COOH, —N(R18)(R19), —C1-C6alkylheteroaryl, —C1-C6alkylN(R18)(R19), —C1-C6alkoxy or —COOC1-C6alkyl;
• R14 is selected from the group consisting of hydrogen, —C3-C6cycloalkyl, —C1-C6alkyl, —C1-C6alkylheteroaryl, or —C1-C6alkylN(R18)(R19);
• R15 is selected from the group consisting of hydrogen, halogen, —OH, —C1-C6alkylOH, —C3-C6cycloalkyl, —C1-C6alkyl, —haloC1-C6alkyl, —COOH, —N(R18)(R19), —C1-C6alkylheteroaryl, —C1-C6alkylN(R18)(R19), —C1-C6alkoxy or —COOC1-C6alkyl;
• R16 is selected from the group consisting of hydrogen, halogen, —OH, —C1-C6alkylOH, —C3-C6cycloalkyl, —C1-C6alkyl, —haloC1-C6alkyl, —COOH, —N(R18)(R19), —C1-C6alkylheteroaryl, —C1-C6alkylN(R18)(R19), —C1-C6alkoxy or —COOC1-C6alkyl;
• R17 is selected from the group consisting of hydrogen, —C3-C6cycloalkyl, —C1-C6alkyl, —C1-C6alkylheteroaryl, and —C1-C6alkylN(R18)(R19);
• R18 is independently selected from the group consisting of hydrogen, —C3-C6cycloalkyl, —haloC1-C6alkyl, —C1-C6alkyl, —C1-C6alkylNH2, —COheterocycle, and —COC1-C6alkyl, wherein the —COC1-C6alkyl can be optionally substituted with one or two substituents selected from the group consisting of —N(R19)(R19), —OH, cycloalkyl, or a 3-7 membered nitrogen containing ring or R18 taken with R19 forms a 3-7 membered nitrogen containing ring;
• and
• R19 is independently selected from the group consisting of hydrogen, —C3-C6cycloalkyl, —haloC1-C6alkyl and —C1-C6alkyl, or R19 taken with R18 forms a 3-7 membered nitrogen containing ring;
• wherein R6 and R7, R9 and R10, R12 and R13, and R15 and R16 cannot be:
• —COOH and —N (R18)(R19), or —N(R18)(R19) and —COOH.