HPK1 antagonists and uses thereof

A compound of formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• Z is CR or N;
• X is a covalent bond or —NR—;
• R1 is selected from the group consistig of C1-6 aliphatic;
• phenyl;
• a 3-7 membered saturated or partially unsaturated monocyclic carbocyclic ring;
• a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• a 3-7 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• and an 8-10 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1-4 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• each of which is substituted with q instances of RC;
• R2 is selected from the group consisting of 6-11 membered saturated, partially unsaturated, or unsaturated fused bicyclic ring having 0-3 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• each of which is substituted with q instances of RC;
• each instance of R3 is independently hydrogen or an optionally substituted C1-6 aliphatic group;
• each instance of RC is independently oxo, halogen, —CN, —NO2, —OR, —SR, —NR2, —S(O)2R, —S(O)2NR2, —S(O)R, —S(O)NR2, —C(O)R, —C(O)OR, —C(O)NR2, —C(O)N(R)OR, —OC(O)R, —OC(O)NR2, —N(R)C(O)OR, —N(R)C(O)R, —N(R)C(O)NR2, —N(R)C(NR)NR2, —N(R)NR2, —N(R)S(O)2NR2, —N(R)S(O)2R, —N═S(O)R2, —S(NR)(O)R, —N(R)S(O)R, —N(R)CN, —P(O)(R)NR2, —P(O)(R)OR or —P(O)R2;
• or each instance of RC is independently an optionally substituted group selected from C1-6 aliphatic;
• phenyl;
• naphthyl;
• a 3-7 membered saturated or partially unsaturated monocyclic carbocyclic ring;
• a 3-7 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from the group consisting of nitrogen, oxygen, phosphorous, silicon and sulfur;
• a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• an 8-10 membered bicyclic heteroaryl ring having 1-5 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• a 5-8 membered saturated or partially unsaturated bridged bicyclic ring having 0-3 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• a 6-11 membered saturated or partially unsaturated spirocyclic ring having 0-3 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• and a 6-11 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• each of which is substituted with r instances of R and s instances of RD;
• each instance of RD is independently oxo, halogen, —CN, —NO2, —OR, —SR, —NR2, —S(O)2R, —S(O)2NR2, —S(O)R, —S(O)NR2, —C(O)R, —C(O)OR, —C(O)NR2, —C(O)N(R)OR, —OC(O)R, —OC(O)NR2, —N(R)C(O)OR, —N(R)C(O)R, —N(R)C(O)NR2, —N(R)C(NR)NR2, —N(R)NR2, —N(R)S(O)2NR2, —N(R)S(O)2R, —N═S(O)R2, —S(NR)(O)R, —N(R)S(O)R, —N(R)CN, —P(O)(R)NR2, —P(O)(R)OR or —P(O)R2;
• each R is independently hydrogen, —CN, halogen, or an optionally substituted group selected from C1-6 aliphatic;
• phenyl;
• naphthyl;
• a 3-7 membered saturated or partially unsaturated monocyclic carbocyclic ring;
• a 3-7 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• an 8-10 membered bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• a 7-12 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1-4 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• a 5-8 membered saturated or partially unsaturated bridged bicyclic ring having 0-3 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• a 6-10 membered saturated or partially unsaturated spirocyclic ring having 0-3 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• and a 6-11 membered saturated or partially unsaturated bicyclic carbocyclic ring having 1-2 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• or:
• two R groups on the same nitrogen are taken together with the nitrogen to form an optionally substituted 4-7 membered monocyclic saturated, partially unsaturated, or heteroaryl ring having, in addition to the nitrogen, 0-3 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• an 8-10 membered bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• or a 7-12 membered saturated or partially unsaturated bicyclic heterocyclic ring having 1-4 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur;
• m is 0, 1, or 2;
• each q is independently 0, 1, 2, 3, or 4;
• each r is independently 0, 1, 2, 3, or 4;
• and
• each s is independently 0, 1, 2, 3, or 4.