Compositions and methods for making and using small molecules for tubulin-targeted therapy in the treatment of cancers and related conditions

A composition comprising at least one compound according to formula (I-D):

• and
• one or more of the following:
• a tag, an inactive moiety or a targeting moiety linked to the compound;
• wherein R5 is selected from:
• and
• R6 is an aryl or a heteroaryl, wherein the aryl and the heteroaryl are each independently unsubstituted or are each independently substituted with one or more of an alkyl, alkenyl alkynyl, alkoxyl, alkylsulfo, alkylamino, halogen, thiol, hydroxyl, nitro, cyano, cycloalkyl, heterocyclyl, heterocyclic alkyl, aryl, heteroaryl, cycloalkoxyl, heterocyclic alkoxyl cycloalkylthio, or heterocyclic alkylthio.

A compound according to formula II-D:

• wherein J is:
• wherein L is:
• and
• wherein K is an aryl or a heteroaryl, wherein the aryl and the heteroaryl are each independently unsubstituted or are independently substituted with one or more groups selected from alkyl, alkenyl, alkynyl, alkoxyl, alkylsulfo, alkylamino, halogen, thiol, hydroxyl, nitro, cyano, cycloalkyl, heterocyclic alkyl, aryl, heterocyclyl, heteroaryl, cycloalkoxyl, heterocyclic alkoxyl, cycloalkylthio, and heterocyclic alkylthio.